The year is winding down, the votes are in, and here are the top five books of 2021, determined by comparing nearly 50 book lists around the internet!

Empire of Pain by Patrick Radden Keefe. (book) (large print book) (ebook) (eaudiobook) Empire of Pain begins with the story of three doctor brothers, Raymond, Mortimer and the incalculably energetic Arthur, who weathered the poverty of the Great Depression and appalling anti-Semitism. Working at a barbaric mental institution, Arthur saw a better way and conducted groundbreaking research into drug treatments. He also had a genius for marketing, especially for pharmaceuticals, and bought a small ad firm. Arthur devised the marketing for Valium, and built the first great Sackler fortune. He purchased a drug manufacturer, Purdue Frederick, which would be run by Raymond and Mortimer. The brothers began collecting art, and wives, and grand residences in exotic locales. Their children and grandchildren grew up in luxury. Forty years later, Raymond’s son Richard ran the family-owned Purdue. The template Arthur Sackler created to sell Valium–co-opting doctors, influencing the FDA, downplaying the drug’s addictiveness–was employed to launch a far more potent product: OxyContin. The drug went on to generate some thirty-five billion dollars in revenue, and to launch a public health crisis in which hundreds of thousands would die. Patrick Radden Keefe is one of the great investigative writers working today, and this nonfiction epic sheds new light on the opioid crisis.

No One is Talking About This by Patricia Lockwood (book) (ebook) (eaudiobook) As this urgent, genre-defying book opens, a woman who has recently been elevated to prominence for her social media posts travels around the world to meet her adoring fans. She is overwhelmed by navigating the new language and etiquette of what she terms “the portal,” where she grapples with an unshakable conviction that a vast chorus of voices is now dictating her thoughts. When existential threats–from climate change and economic precariousness to the rise of an unnamed dictator and an epidemic of loneliness–begin to loom, she posts her way deeper into the portal’s void. An avalanche of images, details, and references accumulate to form a landscape that is post-sense, post-irony, post-everything. “Are we in hell?” the people of the portal ask themselves. “Are we all just going to keep doing this until we die?” Suddenly, two texts from her mother pierce the fray: “Something has gone wrong,” and “How soon can you get here?” As real life and its stakes collide with the increasingly absurd antics of the portal, the woman confronts a world that seems to contain both an abundance of proof that there is goodness, empathy, and justice in the universe, and a deluge of evidence to the contrary.

Harlem Shuffle by Colson Whitehead (book) (audio CD) (ebook) (eaudiobook) To his customers and neighbors on 125th street, Ray Carney is an upstanding salesman of reasonably priced furniture, making a decent life for himself and his family. He and his wife Elizabeth are expecting their second child, and if her parents on Striver’s Row don’t approve of him or their cramped apartment across from the subway tracks, it’s still home. Few people know he descends from a line of uptown hoods and crooks. Cash is tight, especially with all those installment-plan sofas, so if his cousin Freddie occasionally drops off the odd ring or necklace, Ray doesn’t ask where it comes from. Then Freddie falls in with a crew who plan to rob the Hotel Theresa–the “Waldorf of Harlem”–and volunteers Ray’s services as the fence. The heist doesn’t go as planned; they rarely do. Now Ray has a new clientele, one made up of shady cops, vicious local gangsters, two-bit pornographers, and other assorted Harlem lowlifes. Thus begins the internal tussle between Ray the striver and Ray the crook. As Ray navigates this double life, he begins to see who actually pulls the strings in Harlem. Can Ray avoid getting killed, save his cousin, and grab his share of the big score, all while maintaining his reputation as the go-to source for all your quality home furniture needs?

Klara and the Sun by Kazuo Ishiguro (book) (ebook) (eaudiobook) From the best-selling author of Never Let Me Go and The Remains of the Day, a stunning new novel—his first since winning the Nobel Prize in Literature—about the wondrous, mysterious nature of the human heart. Here is the story of Klara, an Artificial Friend with outstanding observational qualities, who, from her place in the store, watches carefully the behavior of those who come in to browse, and of those who pass on the street outside. She remains hopeful that a customer will soon choose her, but when the possibility emerges that her circumstances may change forever, Klara is warned not to invest too much in the promises of humans. Klara and the Sun is a thrilling book that offers a look at our changing world through the eyes of an unforgettable narrator, and one that explores the fundamental question: what does it mean to love?

Detransition, Baby by Torrey Peters (book) (ebook) (eaudiobook) Reese almost had it all: a loving relationship with Amy, an apartment in New York City, a job she didn’t hate. She had scraped together what previous generations of trans women could only dream of: a life of mundane, bourgeois comforts. The only thing missing was a child. But then her girlfriend, Amy, detransitioned and became Ames, and everything fell apart. Now Reese is caught in a self-destructive pattern: avoiding her loneliness by sleeping with married men. Ames isn’t happy either. He thought detransitioning to live as a man would make life easier, but that decision cost him his relationship with Reese–and losing her meant losing his only family. Even though their romance is over, he longs to find a way back to her. When Ames’s boss and lover, Katrina, reveals that she’s pregnant with his baby–and that she’s not sure whether she wants to keep it–Ames wonders if this is the chance he’s been waiting for. Could the three of them form some kind of unconventional family–and raise the baby together?

There you have it, folks! Another wonderful reading year in the books.